| First Author | Reiser H | Year | 1996 |
| Journal | Eur J Immunol | Volume | 26 |
| Issue | 4 | Pages | 880-5 |
| PubMed ID | 8625983 | Mgi Jnum | J:32582 |
| Mgi Id | MGI:80076 | Doi | 10.1002/eji.1830260424 |
| Citation | Reiser H, et al. (1996) Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity. Eur J Immunol 26(4):880-5 |
| abstractText | We analyzed the expression and function of the co-stimulatory molecules B7-1 (CD80) and B7-2 (CD86) during contact sensitivity reactions induced by the hapten 2,4-dinitrofluorobenzene (DNFB). In the normal skin, only a few epidermal Langerhans cells or dermal dendritic cells express B7-2. In contrast, following challenge with DNFB, expression of B7-2 is up-regulated in both epidermis and dermis. Importantly, B7-1 is induced later and at lower levels compared to B7-2. Intravenous injections of anti-B7-2 mAb, but not anti-B7-1 mAb partially inhibit the hapten-induced contact sensitivity reaction. Experiments in which mice are injected differentially with anti-B7-2 mAb, either before the afferent or before the efferent phase of the contact sensitivity response, suggest that B7-2 is important for successful antigen priming. |
