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Publication : Curing APL: differentiation or destruction?

First Author  Kogan SC Year  2009
Journal  Cancer Cell Volume  15
Issue  1 Pages  7-8
PubMed ID  19111876 Mgi Jnum  J:143507
Mgi Id  MGI:3827050 Doi  10.1016/j.ccr.2008.12.012
Citation  Kogan SC (2009) Curing APL: differentiation or destruction?. Cancer Cell 15(1):7-8
abstractText  In a recent issue of Nature Medicine, Nasr et al. show that the effectiveness of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia is independent of their ability to cause differentiation. Targeted destruction of the PML-RARalpha oncoprotein appears key to eliminating the cells from which relapse can arise.
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