First Author | Kogan SC | Year | 2009 |
Journal | Cancer Cell | Volume | 15 |
Issue | 1 | Pages | 7-8 |
PubMed ID | 19111876 | Mgi Jnum | J:143507 |
Mgi Id | MGI:3827050 | Doi | 10.1016/j.ccr.2008.12.012 |
Citation | Kogan SC (2009) Curing APL: differentiation or destruction?. Cancer Cell 15(1):7-8 |
abstractText | In a recent issue of Nature Medicine, Nasr et al. show that the effectiveness of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia is independent of their ability to cause differentiation. Targeted destruction of the PML-RARalpha oncoprotein appears key to eliminating the cells from which relapse can arise. |