| First Author | Ruas JL | Year | 2012 |
| Journal | Cell | Volume | 151 |
| Issue | 6 | Pages | 1319-31 |
| PubMed ID | 23217713 | Mgi Jnum | J:193333 |
| Mgi Id | MGI:5468199 | Doi | 10.1016/j.cell.2012.10.050 |
| Citation | Ruas JL, et al. (2012) A PGC-1alpha isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell 151(6):1319-31 |
| abstractText | PGC-1alpha is a transcriptional coactivator induced by exercise that gives muscle many of the best known adaptations to endurance-type exercise but has no effects on muscle strength or hypertrophy. We have identified a form of PGC-1alpha (PGC-1alpha4) that results from alternative promoter usage and splicing of the primary transcript. PGC-1alpha4 is highly expressed in exercised muscle but does not regulate most known PGC-1alpha targets such as the mitochondrial OXPHOS genes. Rather, it specifically induces IGF1 and represses myostatin, and expression of PGC-1alpha4 in vitro and in vivo induces robust skeletal muscle hypertrophy. Importantly, mice with skeletal muscle-specific transgenic expression of PGC-1alpha4 show increased muscle mass and strength and dramatic resistance to the muscle wasting of cancer cachexia. Expression of PGC-1alpha4 is preferentially induced in mouse and human muscle during resistance exercise. These studies identify a PGC-1alpha protein that regulates and coordinates factors involved in skeletal muscle hypertrophy. |
