| First Author | Nakagawa T | Year | 2000 |
| Journal | Cell | Volume | 103 |
| Issue | 4 | Pages | 569-81 |
| PubMed ID | 11106728 | Mgi Jnum | J:175117 |
| Mgi Id | MGI:5142383 | Doi | 10.1016/s0092-8674(00)00161-6 |
| Citation | Nakagawa T, et al. (2000) A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. Cell 103(4):569-81 |
| abstractText | Intracellular transport mediated by kinesin superfamily proteins (KIFs) is a highly regulated process. The molecular mechanism of KIFs binding to their respective cargoes remains unclear. We report that KIF13A is a novel plus end-directed microtubule-dependent motor protein and associates with beta 1-adaptin, a subunit of the AP-1 adaptor complex. The cargo vesicles of KIF13A contained AP-1 and mannnose-6-phosphate receptor (M6PR). Overexpression of KIF13A resulted in mislocalization of the AP-1 and the M6PR. Functional blockade of KIF13A reduced cell surface expression of the M6PR. Thus, KIF13A transports M6PR-containing vesicles and targets the M6PR from TGN to the plasma membrane via direct interaction with the AP-1 adaptor complex. |
