| Primary Identifier | MGI:1917747 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 70497 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable GTPase activator activity. Predicted to be involved in regulation of Rac protein signal transduction and regulation of actin cytoskeleton organization. Predicted to act upstream of or within actin filament organization and calcium-ion regulated exocytosis. Located in plasma membrane. Is expressed in facial prominence ectoderm; limb; and limb mesenchyme. Orthologous to human ARHGAP17 (Rho GTPase activating protein 17). PHENOTYPE: Mice homozygous for a knock-out allele do not develop spontaneous colitis but show a slight increase in paracellular permeability and increased susceptibility to DSS-induced colitis with rapid destruction of the inner mucus layer. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
