| First Author | Fuss B | Year | 2001 |
| Journal | Mol Cell Neurosci | Volume | 18 |
| Issue | 2 | Pages | 221-34 |
| PubMed ID | 11520182 | Mgi Jnum | J:71481 |
| Mgi Id | MGI:2150222 | Doi | 10.1006/mcne.2001.1011 |
| Citation | Fuss B, et al. (2001) Normal cns myelination in transgenic mice overexpressing mhc class i h-2l(d) in oligodendrocytes. Mol Cell Neurosci 18(2):221-34 |
| abstractText | In demyelinating diseases, such as multiple sclerosis, an upregulation of MHC class I expression is thought to contribute to oligodendrocyte/myelin damage. In order to investigate potential physiological consequences of upregulated MHC class I expression in oligodendrocytes, we generated transgenic mice that overexpress H-2L(d) under the control of the proteolipid protein (PLP) promoter (PLP-L(d) mice). We focused our studies on the MHC class I molecule H-2L(d), because of its unique intracellular transport characteristics. In the CNS of PLP-L(d) mice, H-2L(d) was expressed by oligodendrocytes. Furthermore, H-2L(d) protein was transported to and expressed on the surface of oligodendrocytes. Most importantly, this upregulation of MHC class I expression in the CNS of PLP-L(d) mice did not by itself result in a de- or dysmyelinating phenotype. These transgenic mice are likely to provide a unique and novel tool for the analysis of potential roles of MHC class I-mediated mechanisms in demyelinating pathologies. Copyright 2001 Academic Press. |
