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Publication : Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance.

First Author  Seo S Year  2005
Journal  J Immunol Volume  175
Issue  6 Pages  3492-501
PubMed ID  16148091 Mgi Jnum  J:116716
Mgi Id  MGI:3694862 Doi  10.4049/jimmunol.175.6.3492
Citation  Seo S, et al. (2005) Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance. J Immunol 175(6):3492-501
abstractText  The lymphocyte-specific Cas family protein Cas-L (Crk-associated substrate lymphocyte type) has been implicated to function in lymphocyte movement, mediated mainly by integrin signaling. However, its physiological role is poorly understood. In this study we analyzed the function of Cas-L in lymphocytes using gene-targeted mice. The mutant mice showed a deficit of marginal zone B (MZB) cells and a decrease of cell number in secondary lymphoid organs. An insufficient chemotactic response and perturbed cell adhesion were observed in Cas-L-deficient lymphocytes, suggesting that the aberrant localization was responsible for the deficit of MZB cells. Moreover, we found that lymphocyte trafficking was altered in Cas-L-deficient mice, which gave a potential reason for contraction of secondary lymphoid tissues. Thus, Cas-L affects homeostasis of MZB cells and peripheral lymphoid organs, which is considered to be relevant to impaired lymphocyte migration and adhesion.
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