| First Author | Lau CC | Year | 2014 |
| Journal | Cancer Cell | Volume | 25 |
| Issue | 3 | Pages | 335-49 |
| PubMed ID | 24582836 | Mgi Jnum | J:210525 |
| Mgi Id | MGI:5571407 | Doi | 10.1016/j.ccr.2014.01.030 |
| Citation | Lau CC, et al. (2014) Viral-human chimeric transcript predisposes risk to liver cancer development and progression. Cancer Cell 25(3):335-49 |
| abstractText | The mutagenic effect of hepatitis B (HBV) integration in predisposing risk to hepatocellular carcinoma (HCC) remains elusive. In this study, we performed transcriptome sequencing of HBV-positive HCC cell lines and showed transcription of viral-human gene fusions from the site of genome integrations. We discovered tumor-promoting properties of a chimeric HBx-LINE1 that, intriguingly, functions as a hybrid RNA. HBx-LINE1 can be detected in 23.3% of HBV-associated HCC tumors and correlates with poorer patient survival. HBx-LINE1 transgenic mice showed heightened susceptibility to diethylnitrosamine-induced tumor formation. We further show that HBx-LINE1 expression affects beta-catenin transactivity, which underlines a role in activating Wnt signaling. Thus, this study identifies a viral-human chimeric fusion transcript that functions like a long noncoding RNA to promote HCC. |
