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Allele : Gt(ROSA)26Sor<tm2(CAG-Foxo1*)Mschu> gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Markus Schubert
Primary Identifier  MGI:6861843 Allele Type  Targeted
Attribute String  Conditional ready, Dominant negative, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  The CAG-a loxP site flanked neo-Westphal stop-FLAG-mouse Foxo1* cassette followed by an FRT site-framed IRESeGFP expression cassette were inserted into ROSA26 locus via homologous recombination in the ES cells. The Foxo1 cDNA with deleted transactivation domain acting as dominant-negative Foxo1 transcripts. In presence of cre recombinase, a loxP site flanked neo-Westphal stop sequence is removed to allow expression of mutated Foxo1 gene driven by CAG promoter.
  • mutations:
  • Insertion
  • synonyms:
  • FoxO1DN,
  • FoxO1DN
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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