| Primary Identifier | MGI:96770 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 16842 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including T-helper 1 cell differentiation; positive regulation of cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including blood vessel morphogenesis; brain development; and embryonic morphogenesis. Located in cytoplasm and nucleus. Part of beta-catenin-TCF complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1). PHENOTYPE: Mice homozygous for a null allele are small and die postnatally showing lack of teeth, mammary and uterine glands, whiskers, body hair, dermal-associated fat, and a dentate gyrus, as well as defects in hippocampus morphology, hair follicle development, retinal vasculature, and vascular regression. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
