| First Author | Schell MJ | Year | 1999 |
| Journal | FEBS Lett | Volume | 461 |
| Issue | 3 | Pages | 169-72 |
| PubMed ID | 10567691 | Mgi Jnum | J:58642 |
| Mgi Id | MGI:1349304 | Doi | 10.1016/s0014-5793(99)01462-3 |
| Citation | Schell MJ, et al. (1999) PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase. FEBS Lett 461(3):169-72 |
| abstractText | A cDNA cloned from its ability to stimulate inorganic phosphate uptake in Xenopus oocytes (phosphate uptake stimulator (PiUS)) shows significant similarity with inositol 1,4,5-trisphosphate 3-kinase. However, the expressed PiUS protein showed no detectable activity against inositol 1,4,5-trisphosphate, nor the 1,3,4,5- or 3,4,5, 6-isomers of inositol tetrakisphosphate, whereas it was very active in converting inositol hexakisphosphate (InsP(6)) to inositol heptakisphosphate (InsP(7)). PiUS is a member of a family of enzymes found in many eukaryotes and we discuss the implications of this for the functions of InsP(7) and for the evolution of inositol phosphate kinases. |
