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Allele : Stat1<tm2.1Uvin> signal transducer and activator of transcription 1; targeted mutation 2.1, Uwe Vinkemeier
Primary Identifier  MGI:5588365 Allele Type  Targeted
Gene  Stat1 Transmission  Germline
Strain of Origin  129P2/OlaHsd Is Recombinase  false
Is Wild Type  false
molecularNote  Exon 4 was replaced with a modified exon 4 in which nucleotide substitutions (GAA to GGC) result in the amino acid substitution of alanine for phenylalanine at position 77 (F77A). This mutation abolishes DNA-dependent cooperative multimerization. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • STAT1<F77A>,
  • STAT1<F77A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Carried By

Trail: Allele

0 Driven By

5 Publication categories

Trail: Allele




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