| Primary Identifier | MGI:1098230 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 229841 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables kinetochore binding activity and protein kinase binding activity. Involved in several processes, including attachment of spindle microtubules to kinetochore; establishment of protein localization; and regulation of chromosome segregation. Acts upstream of or within regulation of protein stability and spindle assembly involved in female meiosis I. Located in kinetochore. Part of outer kinetochore. Is expressed in dentate gyrus subgranular zone; testis; and thymus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). PHENOTYPE: Mice homozygous for a knock-out allele display early embryonic lethality. Mutant embryos grown in culture exhibit inner cell mass growth defects and mitotic chromosome misalignment. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
