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Publication : Three receptor genes for plasminogen related growth factors in the genome of the puffer fish Fugu rubripes.

First Author  Cottage A Year  1999
Journal  FEBS Lett Volume  443
Issue  3 Pages  370-4
PubMed ID  10025966 Mgi Jnum  J:52578
Mgi Id  MGI:1329778 Doi  10.1016/s0014-5793(99)00011-3
Citation  Cottage A, et al. (1999) Three receptor genes for plasminogen related growth factors in the genome of the puffer fish Fugu rubripes. FEBS Lett 443(3):370-4
abstractText  Plasminogen related growth factors (PRGFs) and their receptors play major roles in embryogenesis, tissue regeneration and neoplasia. In order to investigate the complexity and evolution of the PRGF receptor family we have cloned and sequenced three receptors for PRGFs in the teleost fish Fugu rubripes, a model vertebrate with a compact genome. One of the receptor genes isolated encodes the orthologue of mammalian MET, whilst the other two may represent Fugu rubripes orthologues of RON and SEA. This is the first time three PRGF receptors have been identified in a single species.
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