| First Author | Peirce JL | Year | 1998 |
| Journal | Mamm Genome | Volume | 9 |
| Issue | 12 | Pages | 942-8 |
| PubMed ID | 9880657 | Mgi Jnum | J:52086 |
| Mgi Id | MGI:1327789 | Doi | 10.1007/s003359900904 |
| Citation | Peirce JL, et al. (1998) A major influence of sex-specific loci on alcohol preference in C57Bl/6 and DBA/2 inbred mice. Mamm Genome 9(12):942-8 |
| abstractText | C57B1/6 mice reproducibly prefer to ingest more 10% ethanol in a two-bottle choice paradigm than do DBA/2J mice. In this paper we report the identification of two new sex-specific alcohol preference (Alcp) loci. Melo and associates (1996) identified two loci: Alcp1, a male- specific locus on Chromosome (Chr) 2, and Alcp2, a female- and cross-specific locus on Chr ll. We have additionally identified Alcp3, a male-specific locus on Chr 3, and Alcp4 a female-specific locus on Chr I. We have also performed a statistical analysis to exclude the possibility of undiscovered major alcohol preference loci that are not sex-specific in our backcross paradigm. Our results indicate that alcohol preference in C57BL/6 mice, as measured in our backcross, is largely controlled in a sex-specific manner. |
