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Allele : Tg(tetO-Fasl)BDepa transgene insertion B, Monique De Paepe
Primary Identifier  MGI:5050406 Allele Type  Transgenic
Attribute String  Inducible, Inserted expressed sequence Gene  Tg(tetO-Fasl)BDepa
Strain of Origin  FVB/N Induced With  doxycycline/tetracycline
Is Recombinase  false Is Wild Type  false
molecularNote  The (tetO)7-FasL transgene was designed with a Tet response element (TRE) upstream of the 943 bp murine Fas ligand (FasL) coding sequence, all followed by a bovine growth hormone intron and polyA sequence. The Tet response element (TRE) contains seven copies of the 42-bp tet operator sequence (tetO) just upstream of a minimal CMV promoter. Five founder lines (A-E) were established. Founder mice from line B were found with ~6 copies of the transgene and high levels of doxycycline-induced FasL mRNA up-regulation.
  • mutations:
  • Insertion
  • synonyms:
  • (tetOp)7-FasL transgenic line B,
  • TetOp-FasL transgenic line B,
  • TetOp-FasL transgenic line B,
  • (tetOp)7-FasL transgenic line B
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