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Protein Domain : Dual oxidase 1/Duox

Primary Identifier  IPR029595 Type  Family
Short Name  DUOX1/Duox
description  This entry includes dual oxidase 1 (DUOX1) from mammals and Duox from fruit flies. DUOX1 and DUOX2 are isoenzymes that belong to the family of NADPH oxidases (Nox) []. They function as calcium-dependent NADPH oxidases producing hydrogen peroxide (H2O2) necessary for thyroid hormone biosynthesis []. Duox is found indispensable for gut antimicrobial activities in fruit flies [].
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