Primary Identifier | MGI:5823259 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Apbb1ip |
Transmission | Germline | Strain of Origin | (C57BL/6 x 129S4/SvJae)F1 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A targeting vector was designed to insert a loxP site upstream of exon 3, and an FRT-flanked neomycin resistance (neo) cassette, followed by a second loxP site, downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 3 through 4 floxed. Subsequent Cre-mediated recombination resulted in the removal of exons 3 and 4 in the germline. |