| Primary Identifier | IPR041291 | Type | Domain |
| Short Name | TUDOR_5 |
| description | This is the first TUDOR domain found in SETDB1 enzymes () from animals, also known as Eggless in Drosophila []. In Drosophila, SetdB1 (Egg) is important for oogenesis and the silencing of chromosome 4 []. SET domain, bifurcated 1 (SETDB1) is a histone methyltransferase (HMT) that methylates lysine 9 on histone H3 (H3K9). The enzymatic activity of SETDB1, in association with MBD1-containing chromatin-associated factor 1 (MCAF1), converts H3K9me2 to H3K9me3 and represses subsequent transcription. SETDB1 is amplified in cancers such as melanoma and lung cancer, and increased expression of SETDB1 promotes tumorigenesis in a zebrafish melanoma model. In addition, SETDB1 is required for endogenous retrovirus silencing during early embryogenesis, inhibition of adipocyte differentiation, and differentiation of mesenchymal cells into osteoblasts []. The tandem Tudor domains in the N-terminal region are involved in protein-protein interactions []. |
