| Primary Identifier | IPR046432 | Type | Family |
| Short Name | TASOR |
| description | TASOR is a key component of the HUSH complex, a vertebrate-specific multiprotein complex that mediates epigenetic repression of both exogenous and endogenous genetic elements [, , ]. The HUSH complex regulates H3K9me3 deposition by promoting recruitment of SETDB1 and also recruits MORC2 to compact chromatin [, , ]. The HUSH complex represses L1 retrotransposons and is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed []. TASOR is crucial in early embryonic development [], and contains a catalytically-inactive PARP domain, necessary for epigenetic regulation of target elements. |
