| First Author | Bornstein P | Year | 1993 |
| Journal | Genomics | Volume | 15 |
| Issue | 3 | Pages | 607-13 |
| PubMed ID | 8468055 | Mgi Jnum | J:4213 |
| Mgi Id | MGI:52710 | Doi | 10.1006/geno.1993.1114 |
| Citation | Bornstein P, et al. (1993) Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene. Genomics 15(3):607-13 |
| abstractText | The DNA sequence of the coding region of the mouse thrombospondin (TSP) 3 gene has been determined by analysis of both genomic and cDNA clones. Like TSP1 and TSP2, TSP3 has a homologous COOH-terminal domain and seven type III (Ca(2+)-binding) repeats. However, TSP3 contains four, rather than three, type II repeats and lacks the type I (TSP or properdin) repeats and procollagen homology characteristic of TSP1 and TSP2. In addition, the NH2-terminal domain of TSP3 differs markedly, both in sequence and in exon/intron structure, from that in TSP1 or TSP2. The gene is located on mouse chromosome 3, bands E3-F1, immediately upstream from the Muc1 (episialin) gene and is expressed in the developing mouse in a pattern that also differs from that of TSP1 or TSP2. Based on its structure, we suggest that TSP3 may play both a unique role in cell-matrix interactions and perform functions that overlap with those of TSP1 and TSP2. |
