| First Author | Ye Z | Year | 2017 |
| Journal | Mol Med Rep | Volume | 16 |
| Issue | 5 | Pages | 6041-6049 |
| PubMed ID | 28849148 | Mgi Jnum | J:271737 |
| Mgi Id | MGI:6282130 | Doi | 10.3892/mmr.2017.7339 |
| Citation | Ye Z, et al. (2017) Subcutaneous injection of dendritic cells aggravates atherosclerosis in ApoEknockout mice by activation of TLR4. Mol Med Rep 16(5):6041-6049 |
| abstractText | Dendritic cells (DCs) are specialized antigenpresenting cells which are important in immune diseases, in particular atherosclerosis, a chronic inflammatory disease, however their role in atherosclerosisassociated immunity is unclear. To evaluate the role of DCs in atherosclerosis, exogenous bone marrowderived DCs were transferred into ApoE/ mice in the present study. The extent of disease was measured in the aorta and was compared with mice treated with phosphatebuffered saline (PBS) or left untreated and fed a western diet. Mice receiving exogenous DCs demonstrated significantly larger atherosclerotic lesions compared with the mice treated with PBS, with increasing numbers of mature DCs in circulation and enhanced DC infiltration into plaque lesions, in addition to activation of circulating inflammatory components and atherosclerotic lesions. Furthermore, it was demonstrated that exogenous DCs upregulated the expression of Tolllike receptor 4 (TLR4) on DCs, which may be an important mechanism to activate DCs and aggravate atherosclerosis. Therefore the present study concluded that exogenous DCs may induce maturation of endogenous DCs via upregulation of TLR4, further increasing the inflammatory response and accelerating atherosclerosis. |
