| First Author | Miyazaki T | Year | 1996 |
| Journal | Science | Volume | 272 |
| Issue | 5260 | Pages | 405-8 |
| PubMed ID | 8602528 | Mgi Jnum | J:32509 |
| Mgi Id | MGI:80003 | Doi | 10.1126/science.272.5260.405 |
| Citation | Miyazaki T, et al. (1996) Independent modes of natural killing distinguished in mice lacking Lag3. Science 272(5260):405-8 |
| abstractText | The LAG3 protein has several features in common with CD4, suggesting that it may be important in controlling T cell reactivity. However, mice with a Lag3 null mutation have now been shown to exhibit a defect in the natural killer cell, rather than the T cell, compartment. Killing of certain tumor targets by natural killer cells from these mice was inhibited or even abolished, whereas lysis of cells displaying major histocompatibility complex class I disparities remained intact. It appears that LAG3 is a receptor or coreceptor that defines different modes of natural killing. |
