| Primary Identifier | MGI:1930780 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 77579 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including RNA binding activity; actin filament binding activity; and adenyl ribonucleotide binding activity. Involved in postsynaptic actin cytoskeleton organization. Acts upstream of or within several processes, including circulatory system development; nervous system development; and plasma membrane repair. Located in several cellular components, including brush border; cytoskeleton; and dendritic spine. Part of myosin II complex. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; early embryo; eye; genitourinary system; and heart and pericardium. Orthologous to human MYH10 (myosin heavy chain 10). PHENOTYPE: Nullizygous mice show pre- and neonatal death, heart defects and hydrocephaly. Deletion of exon B1 disrupts migration of facial neurons, whereas deletion of exon B2 leads to Purkinje cell anomalies. Hypomorphs show hydrocephaly and defects in motor control, cerebellar foliation and neuron migration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
