| Primary Identifier | MGI:1857195 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Il4 |
| Transmission | Germline | Strain of Origin | BALB/cJ |
| Is Recombinase | false | Is Wild Type | false |
| description | Susceptibility to Leishmania major in BALB/c mice has been ablated by introduction of a null mutant of the Il4 gene (J:35236), but in that study the introduced mutant came from a strain 129 background, and 129 is resistant to L. major infection. In mice carrying one of Noben-Trauth's null mutants, targeted in BALB/c embryonic stem cells, the loss of Il4 expression did not remove susceptibility to infection (J:31486). |
| molecularNote | A neomycin resistance cassette was inserted into exon 3 of the gene. |
