| First Author | Miyauchi T | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 5 | Pages | 608-14 |
| PubMed ID | 25643985 | Mgi Jnum | J:220015 |
| Mgi Id | MGI:5632034 | Doi | 10.1016/j.febslet.2015.01.025 |
| Citation | Miyauchi T, et al. (2015) Dynamic subcellular localization of aquaporin-7 in white adipocytes. FEBS Lett 589(5):608-14 |
| abstractText | Aquaporin-7 (AQP7) is expressed in adipose tissue, permeated by water and glycerol, and is involved in lipid metabolism. AQP7-null mice develop obesity, insulin resistance, and adipocyte hypertrophy. Here, we show that AQP7 is expressed in adipocyte plasma membranes, and is re-localized to intracellular membranes in response to catecholamine in mouse white adipose tissue. We found that internalization of AQP7 was induced by PKA activation and comparative gene identification 58 (CGI-58). This relocation was confirmed by functional studies in 3T3-L1 adipocytes. Collectively, these results suggest that AQP7 makes several contributions to adipocyte metabolism, in both cortical and intracellular membranes. |
