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Publication : Developmentally regulated expression of persyn, a member of the synuclein family, in skin.

First Author  Ninkina NN Year  1999
Journal  Exp Cell Res Volume  246
Issue  2 Pages  308-11
PubMed ID  9925745 Mgi Jnum  J:52443
Mgi Id  MGI:1329295 Doi  10.1006/excr.1998.4292
Citation  Ninkina NN, et al. (1999) Developmentally regulated expression of persyn, a member of the synuclein family, in skin. Exp Cell Res 246(2):308-11
abstractText  Synucleins constitute a group of unique, evolutionarily conserved proteins that are expressed predominantly in neurons of the central and peripheral nervous system. Although the normal cellular functions of synucleins are not clear, these proteins have been implicated in various neurodegenerative conditions in humans. We found that persyn, a recently characterized member of the synuclein family, is expressed not only in the nervous system but also in the stratum granulosum of the epidermis of neonatal and adult mice. This finding together with our recent observations that persyn influences neurofilament network integrity in sensory neurons raises the possibility that persyn in skin could be involved in modulation of the keratin network. Copyright 1999 Academic Press.
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