| First Author | Talbot CJ | Year | 2003 |
| Journal | Mamm Genome | Volume | 14 |
| Issue | 4 | Pages | 223-30 |
| PubMed ID | 12682774 | Mgi Jnum | J:82705 |
| Mgi Id | MGI:2654414 | Doi | 10.1007/s00335-002-3059-5 |
| Citation | Talbot CJ, et al. (2003) Fine scale mapping of a genetic locus for conditioned fear. Mamm Genome 14(4):223-30 |
| abstractText | Fear conditioning is one of a number of models for investigating the genetic basis of individual variation in emotion and learning. Genetic mapping using crosses between strains of laboratory mice has identified a locus on chromosome one that appears to influence not only variation in conditioned fear, but also in other validated tests of fear-related behaviour, (including the open-field and the elevated-plus maze), suggesting that the rodent locus may act in ways consistent with how a locus influencing susceptibility to anxiety in humans is believed to operate. Here we use high-resolution mapping in genetically heterogeneous mice to show that a quantitative trait locus influencing conditioned fear can be separated from loci influencing open-field activity. Mapping in two different heterogeneous stocks, the Boulder and Northport HS, gave similar map locations for open-field activity at two positions on the current mouse physical map, one at 162 Mb on chromosome one (negative log P-value 5.4) the other at 173 Mb (negative log P-value 4.8), while mapping of contextual conditioned fear in the Boulder HS identified a locus at 170 Mb (negative log P-value 5.4). Estimates of the 95% confidence intervals show that the locations do not overlap. The region containing a gene or genes that influence variation in conditioned fear is approximately 1 megabase in size and contains only one gene of known function, a pre-B cell leukaemia factor. |
