| First Author | Diriong S | Year | 1994 |
| Journal | Hum Genet | Volume | 93 |
| Issue | 6 | Pages | 703-6 |
| PubMed ID | 8005598 | Mgi Jnum | J:46048 |
| Mgi Id | MGI:1197027 | Doi | 10.1007/BF00201576 |
| Citation | Diriong S, et al. (1994) Assignment of the human 8.5 H gene to chromosome 5, region 5q35. Hum Genet 93(6):703-6 |
| abstractText | The human 8.5 H probe was isolated from a human cerebellum cDNA library with a probe corresponding to the coding region of the murine 8.5 M cDNA. This cDNA isolated from a murine cDNA library constructed from newborn cerebral hemispheres was selected because of its strong expression in embryonic neurons. Consequently the corresponding human gene could be a candidate for hereditary neurodegenerative diseases. The human 8.5 H gene was assigned by somatic hybrid analysis to chromosome 5; this chromosome contains the gene(s) for spinal muscular atrophy (SMA), a group of heritable degenerative diseases that selectively affect the anterior horn motor neuron of the spinal cord. The localization by in situ hybridization of 8.5 H on 5q35 excluded the possibility that this gene is identical to SMA. The SMA gene(s) was (were) known, from linkage analysis, to be in a region (5q11.2-q13.3) very distant from 5q35. |
