| First Author | Shats I | Year | 2003 |
| Journal | FEBS Lett | Volume | 546 |
| Issue | 2-3 | Pages | 321-4 |
| PubMed ID | 12832061 | Mgi Jnum | J:84365 |
| Mgi Id | MGI:2667493 | Doi | 10.1016/s0014-5793(03)00607-0 |
| Citation | Shats I, et al. (2003) The murine telomerase catalytic subunit shares the PAb-240 mutant specific epitope of the p53 protein. FEBS Lett 546(2-3):321-4 |
| abstractText | Many tumorigenic p53 mutants gain a common antigenic epitope that is recognized by the PAb-240 antibody. Database search identified the presence of this epitope in several other proteins, including several antibodies and the catalytic subunit of mouse telomerase, mTERT. These antibodies may represent a part of the previously demonstrated anti-idiotypic network built around p53. In the present study we demonstrate that the PAb-240 antibody was able to inhibit telomerase activity in extracts from both mouse and human tumor cells. The recognition of mTERT by PAb-240 is demonstrated by Western blotting and by using blocking peptides derived from mTERT. The existence of a shared epitope between mutant p53 and telomerase may suggest that the two proteins contribute to malignant transformation through a common pathway. |
