| First Author | Goss KH | Year | 2002 |
| Journal | Science | Volume | 297 |
| Issue | 5589 | Pages | 2051-3 |
| PubMed ID | 12242442 | Mgi Jnum | J:79058 |
| Mgi Id | MGI:2387056 | Doi | 10.1126/science.1074340 |
| Citation | Goss KH, et al. (2002) Enhanced tumor formation in mice heterozygous for Blm mutation. Science 297(5589):2051-3 |
| abstractText | Persons with the autosomal recessive disorder Bloom syndrome are predisposed to cancers of many types due to loss-of-function mutations in the BLM gene, which encodes a recQ-like helicase. Here we show that mice heterozygous for a targeted null mutation of Blm, the murine homolog of BLM, develop lymphoma earlier than wild-type littermates in response to challenge with murine leukemia virus and develop twice the number of intestinal tumors when crossed with mice carrying a mutation in the Apc tumor suppressor. These observations indicate that Blm is a modifier of tumor formation in the mouse and that Blm haploinsufficiency is associated with tumor predisposition, a finding with important implications for cancer risk in humans. |
