| First Author | Welten SPM | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 2295 |
| PubMed ID | 32385253 | Mgi Jnum | J:323565 |
| Mgi Id | MGI:6447249 | Doi | 10.1038/s41467-020-16219-3 |
| Citation | Welten SPM, et al. (2020) Tcf1(+) cells are required to maintain the inflationary T cell pool upon MCMV infection. Nat Commun 11(1):2295 |
| abstractText | Cytomegalovirus-based vaccine vectors offer interesting opportunities for T cell-based vaccination purposes as CMV infection induces large numbers of functional effector-like cells that accumulate in peripheral tissues, a process termed memory inflation. Maintenance of high numbers of peripheral CD8 T cells requires continuous replenishment of the inflationary T cell pool. Here, we show that the inflationary T cell population contains a small subset of cells expressing the transcription factor Tcf1. These Tcf1(+) cells resemble central memory T cells and are proliferation competent. Upon sensing viral reactivation events, Tcf1(+) cells feed into the pool of peripheral Tcf1(-) cells and depletion of Tcf1(+) cells hampers memory inflation. TCR repertoires of Tcf1(+) and Tcf1(-) populations largely overlap, with the Tcf1(+) population showing higher clonal diversity. These data show that Tcf1(+) cells are necessary for sustaining the inflationary T cell response, and upholding this subset is likely critical for the success of CMV-based vaccination approaches. |
