| Primary Identifier | MGI:96930 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 328949 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial cell migration; and negative regulation of epithelial cell proliferation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including embryo mesenchyme; gut; nervous system; primitive streak; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human MCC (MCC regulator of WNT signaling pathway). PHENOTYPE: Mice homozygous for hypomorphic or null mutations are viable and fertile with no gross abnormalities. Conditional knockout in colonic and intestinal epithelial cells exacerbates inflammation-associated carcinogenesis in the colon. Constitutive KO affects DNA repair. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
