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Allele : Tg(Myh6-MYL3*E143K)2Dsc transgene insertion 2, Danuta Szczesna-Cordary
Primary Identifier  MGI:6315994 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(Myh6-MYL3*E143K)2Dsc
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  The human cardiac myosin essential light chain containing a glutamate to lysine change at amino acid 143 (E143K) is under the control of the cardiac specific alpha-MHC promoter. This mutation has been associated with restrictive cardiomyopathy in humans. Line 2 expresses about 55% of human essential light chain replacing the endogenous mouse cardiac essential light chain.
  • mutations:
  • Insertion
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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3 Publication categories

Trail: Allele




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