Primary Identifier | MGI:1930958 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 83813 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in negative regulation of Ras protein signal transduction and negative regulation of cell growth. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; pituitary gland; respiratory system; and thymus. Orthologous to human TNK1 (tyrosine kinase non receptor 1). PHENOTYPE: Mice either heterozygous or homozygous for a knock-out allele develop spontaneous tumors, including lymphomas and carcinomas, at high rates. [provided by MGI curators] |