| Primary Identifier | IPR028760 | Type | Family |
| Short Name | Ski |
| description | Ski is involved in oncogenic transformation and enhancement of muscle differentiation by blocking TGF-beta signaling [, ]. Ski binds directly to the Smad3/4 complex and negatively regulates TGF-beta signaling [, , ]. It plays a role in terminal differentiation of skeletal muscle cells, but not in the determination of cells to the myogenic lineage []. Ski is a component of the histone deacetylase complex (HDAC) complex and is required for the transcriptional repression mediated by this complex []. This entry includes v-ski (viral oncogene ski) from the avian Sloan-Kettering retroviruses and its homologue from animals, c-ski []. c-ski can promote cancer progression and is highly expressed in some of solid cancers including leukemia, melanoma, colorectal cancer, gastric cancer and pancreatic cancer []. However, it can also act as a tumour suppressor in some cases []. |
