| First Author | Nicholls RE | Year | 2008 |
| Journal | Neuron | Volume | 58 |
| Issue | 1 | Pages | 104-17 |
| PubMed ID | 18400167 | Mgi Jnum | J:135145 |
| Mgi Id | MGI:3790528 | Doi | 10.1016/j.neuron.2008.01.039 |
| Citation | Nicholls RE, et al. (2008) Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility. Neuron 58(1):104-17 |
| abstractText | While most studies have focused on the role of long-term potentiation in behavior, far less is known about the role of long-term depression (LTD). To examine the potential involvement of LTD in learning and memory, we generated transgenic mice that express a fragment of the SV40 small t antigen known to inhibit protein phosphatase 2A (PP2A). Small t antigen expression blocked both stimulus-induced and chemically induced NMDAR-dependent LTD at Schaffer collateral synapses but did not affect potentiation, depotentiation, or mGluR-dependent LTD. This physiological phenotype was associated with deficits in behavioral flexibility in both the Morris water maze and a delayed nonmatch to place T-maze task, suggesting that NMDAR-dependent LTD is required for behavioral flexibility and may act by weakening previously encoded memory traces when new information is learned. |
