| Type | MGI:General | Description | as early as P5, mutant males display Sertoli cell nuclear mislocalization with almost complete absence of lumen at P15, mutant Sertoli cell nuclei display an abnormal circular rather than flattened triangular shape a 1.25-, 1.5-, and 2.6-fold increase in Sertoli cell proliferation is observed at P0, P5, and P15, respectively, suggesting delayed Sertoli cell maturation significant Sertoli cell apoptosis is noted at P5; however, by P21, apoptotic cells are almost exclusively germ cells by 3 months of age, obvious defects in Sertoli cell cyto-architecture and polarity are observed |
