| First Author | Hwang JY | Year | 2022 |
| Journal | Cell Rep | Volume | 38 |
| Issue | 3 | Pages | 110226 |
| PubMed ID | 34998468 | Mgi Jnum | J:321418 |
| Mgi Id | MGI:6874530 | Doi | 10.1016/j.celrep.2021.110226 |
| Citation | Hwang JY, et al. (2022) C2cd6-encoded CatSpertau targets sperm calcium channel to Ca(2+) signaling domains in the flagellar membrane. Cell Rep 38(3):110226 |
| abstractText | In mammalian sperm cells, regulation of spatiotemporal Ca(2+) signaling relies on the quadrilinear Ca(2+) signaling nanodomains in the flagellar membrane. The sperm-specific, multi-subunit CatSper Ca(2+) channel, which is crucial for sperm hyperactivated motility and male fertility, organizes the nanodomains. Here, we report CatSpertau, the C2cd6-encoded membrane-associating C2 domain protein, can independently migrate to the flagella and serve as a major targeting component of the CatSper channel complex. CatSpertau loss of function in mice demonstrates that it is essential for sperm hyperactivated motility and male fertility. CatSpertau targets the CatSper channel into the quadrilinear nanodomains in the flagella of developing spermatids, whereas it is dispensable for functional channel assembly. CatSpertau interacts with ciliary trafficking machinery in a C2-dependent manner. These findings provide insights into the CatSper channel trafficking to the Ca(2+) signaling nanodomains and the shared molecular mechanisms of ciliary and flagellar membrane targeting. |
