| Primary Identifier | MGI:105115 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 13019 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable cytokine activity and leukemia inhibitory factor receptor binding activity. Acts upstream of or within neuron development. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; gut; and heart and pericardium. Used to study abdominal obesity-metabolic syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CTF1 (cardiotrophin 1). PHENOTYPE: Mice homozygous for a knock-out allele show a significant reduction in grip strength and increased motoneuron cell death in the spinal cord and brainstem nuclei between embryonic day 14 and the first postnatal week. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
