| First Author | Jiang W | Year | 2009 |
| Journal | J Immunol | Volume | 182 |
| Issue | 6 | Pages | 3768-74 |
| PubMed ID | 19265155 | Mgi Jnum | J:145917 |
| Mgi Id | MGI:3836325 | Doi | 10.4049/jimmunol.0800973 |
| Citation | Jiang W, et al. (2009) TLR-9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells. J Immunol 182(6):3768-74 |
| abstractText | Increasing evidence suggests that TLRs are involved in the pathogenesis of liver diseases; however, the underlying mechanisms remain obscure. In this study, we found that treatment with CpG-oligodeoxynucleotide (ODN) promoted the accumulation and activation of murine hepatic NKT cells. Additional experiments showed that CpG-ODN preferred to act on CD4(+) NKT cells, while having less effect on CD4(-) NKT cells. The effect of CpG-ODN on liver NKT cells depended on the presence of Kupffer cells and IL-12. Meanwhile, CpG-ODN pretreatment aggravated liver injury and promoted the production of inflammatory cytokines in a Con A-induced fulminant hepatitis model via TLR9 activation. Collectively, our data demonstrate that TLR9 stimulation prefers to promote the accumulation and activation of hepatic CD4(+) NKT cells and suggest that TLR9 signaling might be involved in the pathogenesis of human hepatitis. |
