| Primary Identifier | MGI:1096362 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 18190 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including calcium channel regulator activity; cell adhesion molecule binding activity; and neuroligin family protein binding activity. Involved in several processes, including postsynapse organization; presynaptic modulation of chemical synaptic transmission; and regulation of postsynapse assembly. Acts upstream of or within neurotransmitter secretion and synapse assembly. Part of protein-containing complex. Is active in glutamatergic synapse and presynaptic active zone membrane. Is expressed in several structures, including blood vessel; nervous system; and retina. Used to study autism spectrum disorder. Orthologous to human NRXN2 (neurexin 2). PHENOTYPE: Mice homozygous for a knock-out allele are generally non-viable; surviving homozygotes show a 30-40% decrease in body weight and their inhibitory postsynaptic currents (IPSCs) are decreased in cortical slice cultures. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
