Primary Identifier | IPR027574 | Type | Family |
Short Name | Thiaminase_II |
description | The TenA protein of Bacillus subtilis and Staphylococcus aureus [, ], and the C-terminal region of trifunctional protein Thi20p from Saccharomyces cerevisiae [], perform cleavages on thiamine and related compounds to produce 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), a substrate of a salvage pathway for thiamine biosynthesis. The gene symbol tenA, for Transcription ENhancement A, reflects a misleading early characterisation as a regulatory protein. This family is related to PqqC from the PQQ biosynthesis system , heme oxygenase , and CADD (Chlamydia protein Associating with Death Domains), a putative folate metabolism enzyme . |