| First Author | Buckbinder L | Year | 1997 |
| Journal | Proc Natl Acad Sci U S A | Volume | 94 |
| Issue | 15 | Pages | 7868-72 |
| PubMed ID | 9223279 | Mgi Jnum | J:41940 |
| Mgi Id | MGI:894852 | Doi | 10.1073/pnas.94.15.7868 |
| Citation | Buckbinder L, et al. (1997) The p53 tumor suppressor targets a novel regulator of G protein signaling. Proc Natl Acad Sci U S A 94(15):7868-72 |
| abstractText | Heterotrimeric G proteins transduce multiple growth-factor-receptor-initiated and intracellular signals that may lead to activation of the mitogen-activated or stress-activated protein kinases. Herein we report on the identification of a novel p53 target gene (A28-RGS14) that is induced in response to genotoxic stress and encodes a novel member of a family of regulators of G protein signaling (RGS) proteins with proposed GTPase-activating protein activity. Overexpression of A28-RGS14p protein inhibits both Gi- and Gq-coupled growth-factor-receptor-mediated activation of the mitogen-activated protein kinase signaling pathway in mammalian cells. Thus, through the induction of A28-RGS14, p53 may regulate cellular sensitivity to growth and/or survival factors acting through G protein-coupled receptor pathways. |
