| First Author | Wanzel M | Year | 2005 |
| Journal | Nat Cell Biol | Volume | 7 |
| Issue | 1 | Pages | 30-41 |
| PubMed ID | 15580267 | Mgi Jnum | J:95661 |
| Mgi Id | MGI:3526757 | Doi | 10.1038/ncb1202 |
| Citation | Wanzel M, et al. (2005) Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage. Nat Cell Biol 7(1):30-41 |
| abstractText | The transcription factor Miz1 is required for DNA-damage-induced cell-cycle arrest. We have now identified 14-3-3eta as a gene that inhibits Miz1 function through interaction with its DNA binding domain. Binding of 14-3-3eta to Miz1 depends on phosphorylation by Akt and regulates the recovery of cells from arrest after DNA damage. Miz1 has two functions in response to DNA damage: first, it is required for upregulation of a large group of genes, a function that is regulated by c-Myc, but not by 14-3-3eta; second, Miz1 represses the expression of many genes in response to DNA damage in an Akt- and 14-3-3eta-regulated manner. |
