| First Author | Arnold B | Year | 1984 |
| Journal | Nucleic Acids Res | Volume | 12 |
| Issue | 24 | Pages | 9473-87 |
| PubMed ID | 6096831 | Mgi Jnum | J:68861 |
| Mgi Id | MGI:1933554 | Doi | 10.1093/nar/12.24.9473 |
| Citation | Arnold B, et al. (1984) Complete nucleotide sequence of the murine H-2Kk gene. Comparison of three H-2K locus alleles. Nucleic Acids Res 12(24):9473-87 |
| abstractText | We have determined the DNA sequence of the H-2Kk gene of the mouse major histocompatibility complex (MHC). Comparison on the nucleotide and protein level of three H-2K alleles (Kk, Kb and Kd) reveals a high degree of homology, in particular between the Kb and Kk alleles. Differences between the two latter antigens are almost exclusively confined to the alpha 1 and alpha 2 domains. At nine positions in the extracellular part of the molecules we have found allele-specific amino acids. Interestingly, 78% of these residues are either polar or carry hydroxyl-groups. This makes it likely that they are exposed on the surface of the molecules and might then be part of antigenic determinants. We have also identified potentially allele-specific nucleotide sequences of the K genes which might be used as specific DNA probes. |
