Primary Identifier | MGI:1341149 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 11642 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables protein kinase A binding activity. Acts upstream of or within blastocyst hatching; cell surface receptor protein serine/threonine kinase signaling pathway; and protein localization. Located in acrosomal vesicle; sperm fibrous sheath; and sperm principal piece. Is expressed in early conceptus; secondary oocyte; and spermatocyte. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human AKAP3 (A-kinase anchoring protein 3). PHENOTYPE: Mice homozygous for a null allele exhibit male infertility associated with decreased hyperactivated sperm motility and abnormal sperm flagellum. [provided by MGI curators] |