| First Author | Cash-Padgett T | Year | 2016 |
| Journal | Neurosci Res | Volume | 105 |
| Pages | 75-9 | PubMed ID | 26458529 |
| Mgi Jnum | J:231840 | Mgi Id | MGI:5775243 |
| Doi | 10.1016/j.neures.2015.10.001 | Citation | Cash-Padgett T, et al. (2016) Increased stereotypy in conditional Cxcr4 knockout mice. Neurosci Res 105:75-9 |
| abstractText | Chemokines play important roles in the central nervous system, including mediating neuroinflammation and guiding the intracortical migration of interneurons during development. Alteration in parvalbumin-positive interneurons is a key neuropathological hallmark of multiple mental conditions. We recently reported a significant reduction in the expression of CXCL12 in olfactory neurons from sporadic cases with schizophrenia compared with matched controls, suggesting a role for CXCR4/CXCL12 signaling in mental conditions. Thus, we depleted the chemokine receptor Cxcr4 from mice using the parvalbumin-2A-Cre line. The conditional knockout mice exhibited a unique behavioral phenotype involving increased stereotypy. Stereotypy is observed in many psychiatric conditions, including schizophrenia, autism, and dementia. Thus, the Cxcr4 conditional knockout mice may serve as a model for this symptomatic feature. |
