| First Author | Yamashita N | Year | 2005 |
| Journal | Cell Immunol | Volume | 235 |
| Issue | 2 | Pages | 85-91 |
| PubMed ID | 16168397 | Mgi Jnum | J:107949 |
| Mgi Id | MGI:3622584 | Doi | 10.1016/j.cellimm.2005.07.006 |
| Citation | Yamashita N, et al. (2005) Role of insulin-like growth factor-I in allergen-induced airway inflammation and remodeling. Cell Immunol 235(2):85-91 |
| abstractText | Insulin-like growth factor (IGF)-I is known to act on fibroblasts as a progression factor to push cells toward proliferation and activation to synthesize collagen. Subepithelial fibrosis, collagen deposition at the lamina reticularis, is part of the process of so-called remodeling and is a characteristic finding in the asthmatic airway. To study the role of IGF in the evolution of asthma, we used a model that involved immunization of mice with ovalbumin and alum, followed by an inhaled challenge of ovalbumin. IGF-I neutralizing antibody was continuously infused with an osmotic pump. Pulmonary function was analyzed using whole-body plethysmography before and after acetylcholine administration. It was found that OVA inhalation induced IGF-I expression at the site of the airway. IGF-I neutralizing Ab inhibited the elevation of airway resistance, airway inflammation, and an increase in airway wall thickening. The depression of ICAM-1 expression was accompanied by a diminution in airway inflammation. In conclusion, these results suggest that IGF-I is likely to be an important mediator of inflammation and remodeling in the asthmatic airway. |
