| First Author | Serizawa S | Year | 2006 |
| Journal | Cell | Volume | 127 |
| Issue | 5 | Pages | 1057-69 |
| PubMed ID | 17129788 | Mgi Jnum | J:144662 |
| Mgi Id | MGI:3831481 | Doi | 10.1016/j.cell.2006.10.031 |
| Citation | Serizawa S, et al. (2006) A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting. Cell 127(5):1057-69 |
| abstractText | In the mouse, olfactory sensory neurons (OSNs) expressing the same odorant receptor (OR) converge their axons to a specific set of glomeruli in the olfactory bulb. To study how OR-instructed axonal fasciculation is controlled, we searched for genes whose expression profiles are correlated with the expressed ORs. Using the transgenic mouse in which the majority of OSNs express a particular OR, we identified such genes coding for the homophilic adhesive molecules Kirrel2/Kirrel3 and repulsive molecules ephrin-A5/EphA5. In the CNGA2 knockout mouse, where the odor-evoked cation influx is disrupted, Kirrel2 and EphA5 were downregulated, while Kirrel3 and ephrin-A5 were upregulated, indicating that these genes are transcribed in an activity-dependent manner. Mosaic analysis demonstrated that gain of function of these genes generates duplicated glomeruli. We propose that a specific set of adhesive/repulsive molecules, whose expression levels are determined by OR molecules, regulate the axonal fasciculation of OSNs during the process of glomerular map formation. |
